Collaborative Resources for
Learning Developmental Biology
Collaborative Resources for Learning Developmental Biology
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Neural Fold Closure
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Richard Harland

Published on SDB CoRe: Mar 4 2013

Morphogenic Movements: Neurulation
Morphogenesis: Cell Movements
Ectoderm-derived: Nervous System
Organism: Axolotl
Stage of Development: Embryo

Object Description

This time-lapse movie depicts neural tube closure in an axolotl (Ambystoma mexicanum) embryo.  Fusion of the two neural folds into one neural tube can be seen in the anterior region of the embryo.   This portion of the neural tube will form the brain and the remainder will form the spinal cord.


Wallingford, J.B., Harland, R.M. Neural tube closure requires Dishevelled-dependent convergent extension of the midline. Development, 2002, 12:5815-5825.

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